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WRAP News
The WRAP study celebrates 25 years!
What began with a single participant has grown into one of the world’s largest and longest-running studies focused on identifying factors that influence brain health and Alzheimer’s disease risk. To commemorate the 25th anniversary of the Wisconsin Registry for Alzheimer’s Prevention (WRAP), a recent episode of the Dementia Matters podcast brought together three leaders whose work has been instrumental to WRAP’s success: Dr. Mark Sager, WRAP co-founder, and current WRAP multi-principal investigators Dr. Sterling Johnson and Dr. Jessica Caldwell.
How a recent Harvard-led Alzheimer’s study uses WRAP data
A new study by researchers at Harvard University and presented at the 2026 Alzheimer’s Association International Conference is generating news for its findings that a simple blood test may help predict future cognitive decline, paving the way for researchers to identify effective strategies for Alzheimer’s prevention. The study analyzed data from nearly 2,700 cognitively unimpaired adults across six international research cohorts, including participants from the Wisconsin Registry for Alzheimer’s Prevention.
Dr. Nathaniel Chin publishes book on navigating Alzheimer’s disease and dementia care
A new book by Nathaniel Chin, MD, When Memory Fades: What to Expect at Every Stage, from Early Signs to Full Support for Alzheimer’s and Dementia, offers a clear and compassionate guide for people navigating Alzheimer’s disease and related dementias.
Midlife, menopause, and the brain: New insights from Dr. Jessica Caldwell
Caldwell’s research reframes common experiences like “brain fog” during menopause as both real and measurable, yet often temporary. Framing midlife as a window of opportunity, when interventions such as sleep and stress management, consistent physical activity, and addressing cardiovascular health may help protect the brain over time.
Dr. Kimberly Mueller discusses WRAP, early interventions in Alzheimer’s disease
In a recent interview on the La Crosse, WI area radio station WIZM, Kimberly Mueller, PhD, CCC-SLP, shared updates on how Alzheimer’s disease is being detected earlier, and how the WRAP research study is helping lead those advances. Mueller is an associate professor at the University of Wisconsin–Madison and an investigator in the UW–Madison Alzheimer’s disease research programs, including our WRAP study.
New WRAP newsletter highlights milestones, research advances, and leadership updates
The winter 2026 edition of our WRAP Newsletter is now available, offering a look at new research, program milestones, and team updates.
New policy proposal charts the future of early Alzheimer’s treatment
WRAP mPI Sterling Johnson, PhD, is co-author of a forthcoming Policy View in the March issue of The Lancet Neurology. The paper offers recommendations in Alzheimer’s disease treatment and prevention, with important considerations for treatments in people who are cognitively unimpaired but at risk of future symptoms.
Dr. Jessica Caldwell explores gender differences in Alzheimer’s disease as new WRAP study leader
Caldwell joined UW–Madison in September 2025 as the multi-principal investigator of the Wisconsin Registry for Alzheimer’s Prevention study
That’s a wrap!
Watch a recording and find details from the 2025 WRAP Info Sessions