a series of four photos of older adults

Amyloid Disclosure Study

The Wisconsin Registry for Alzheimer’s Prevention (WRAP) is beginning a new study called the Amyloid Disclosure Study to examine how people respond to learning their amyloid PET scan results.

The study will consist of:

  • Three 1.5 hour in-person/virtual visits
    1. Informed consent and education session
    2. Education session and disclosure of the beta-amyloid PET scan result
    3. Personalized lifestyle counseling session with a study clinician
  • Three brief phone visits (30 minutes)

Study Timeline

study timeline description

(click timeline to view full-screen version)

Study Goals

Goal: Develop an infrastructure to support a responsible approach to Alzheimer’s disease biomarker disclosure.

set of colored rings describing the process of the study: screening, education, disclosure, care planning, and follow-up

Goal: Investigate personal impacts of amyloid disclosure.

info graphic showing possible impacts of amyloid disclosure

Who Is Eligible?

Eligible participants for this study are those that have completed or can complete an amyloid PET scan in WRAP (or PREDICT) and are 65 or older. Today, using amyloid PET brain scans, researchers and doctors can see where and how much amyloid is present in a person’s brain. The Wisconsin Registry for Alzheimer’s Prevention (WRAP) is using brain scans to understand the role of amyloid in Alzheimer’s disease.

About Amyloid

illustration showing amyloid plaque and neuron in the brain
Our brains are made of cells called neurons. Amyloid plaques are abnormal clusters of a protein that builds up between neurons. Credit: CNP520A2202J – Generation Study 2 Amyloid Disclosure Session – Version 1

Amyloid is a protein produced normally in the brain, but in people with Alzheimer’s disease it accumulates abnormally causing plaques that interfere with brain cell (neuron) communication. Amyloid plaques are not normal and are always found in the brains of patients with dementia due to Alzheimer’s disease. This buildup of amyloid begins many years, perhaps decades, before symptoms of memory loss appear.

amyloid PET scans
This picture shows an example of an amyloid PET scan. The red color represents the presence of elevated amyloid protein in the brain.

Meet Our Study Team

Lindsay Clark, PhD

Position title: Principle Investigator

Email: lrclark@medicine.wisc.edu

Phone: (608) 263-4405

Address:
600 Highland Avenue
Madison, WI 53792

Nathaniel Chin, MD

Position title: Study Clinician

Address:
600 Highland Avenue
Madison, WI 53792

Claire Erickson, MPA

Position title: Graduate Research Assistant

Email: cmerickson4@wisc.edu

Address:
Wisconsin Institute for Medical Research
1111 Highland Avenue
Madison, WI 53705

Hannah Rosario, BS

Position title: Study Coordinator

Email: hrosario@medicine.wisc.edu

Phone: 608-890-4150

Address:
Clinical Science Center
600 Highland Avenue
Madison, WI 53792

Learn More

If you are an enrolled participant, use the links below to access study materials when instructed. (The links for these materials are password protected; your study coordinator will provide the password.)

Webex tutorials

Visit 1

Visit 2

Visit 3

At-home questionnaire