White matter microstructure in late middle-age: Effects of apolipoprotein E4 and parental family history of Alzheimer’s disease.

Adluru, N., D. Destiche, S. Lu, S. Doran, A. Birdsill, K. Melah, O. Okonkwo, A. Alexander, N. Dowling, S. Johnson, M. Sager, and B. Bendlin. “White Matter Microstructure in Late Middle-Age: Effects of Apolipoprotein E4 and Parental Family History of Alzheimer’s Disease.”. NeuroImage. Clinical, Vol. 4, 2014, pp. 730-42.

Little is still known about the effects of risk factors for Alzheimer’s disease (AD) on white matter microstructure in cognitively healthy adults. The purpose of this cross-sectional study was to assess the effect of two well-known risk factors for AD, parental family history and APOE4 genotype.

DOI: 10.1016/j.nicl.2014.04.008

PubMed: 24936424