White matter is altered with parental family history of Alzheimer’s disease.

Bendlin, B., M. Ries, E. Canu, A. Sodhi, M. Lazar, A. Alexander, C. Carlsson, M. Sager, S. Asthana, and S. Johnson. “White Matter Is Altered With Parental Family History of Alzheimer’s Disease.”. Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association, Vol. 6, no. 5, 2010, pp. 394-03.

Brain alterations in structure and function have been identified in people with risk factors for sporadic type Alzheimer’s disease (AD), suggesting that alterations can be detected decades before AD diagnosis. Although the effect of apolipoprotein E (APOE) varepsilon4 on the brain is well-studied, less is known about the effect of family history of AD. We examined the main effects of family history and APOE varepsilon4 on brain integrity, in addition to assessing possible additive effects of these two risk factors.

DOI: 10.1016/j.jalz.2009.11.003

PubMed: 20713315