The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease.

Vogt, N., K. Romano, B. Darst, C. Engelman, S. Johnson, C. Carlsson, S. Asthana, K. Blennow, H. Zetterberg, B. Bendlin, and F. Rey. “The Gut Microbiota-Derived Metabolite Trimethylamine N-Oxide Is Elevated in Alzheimer’s Disease.”. Alzheimer’s Research & Therapy, Vol. 10, no. 1, 2018, p. 124.

Trimethylamine N-oxide (TMAO), a small molecule produced by the metaorganismal metabolism of dietary choline, has been implicated in human disease pathogenesis, including known risk factors for Alzheimer’s disease (AD), such as metabolic, cardiovascular, and cerebrovascular disease.

DOI: 10.1186/s13195-018-0451-2

PubMed: 30579367