Hohman, T., L. Dumitrescu, L. Barnes, M. Thambisetty, G. Beecham, B. Kunkle, K. Gifford, W. Bush, L. Chibnik, S. Mukherjee, J. De, W. Kukull, P. Crane, S. Resnick, C. Keene, T. Montine, G. Schellenberg, J. Haines, H. Zetterberg, K. Blennow, E. Larson, S. Johnson, M. Albert, D. Bennett, J. Schneider, A. Jefferson, and D. Alzheimer’s. “Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau.”. JAMA Neurology, Vol. 75, no. 8, 2018, pp. 989-98.
The strongest genetic risk factor for Alzheimer disease (AD), the apolipoprotein E (APOE) gene, has a stronger association among women compared with men. Yet limited work has evaluated the association between APOE alleles and markers of AD neuropathology in a sex-specific manner.
DOI: 10.1001/jamaneurol.2018.0821
PubMed: 29801024