Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer’s disease.

Dougherty, R., S. Schultz, E. Boots, L. Ellingson, J. Meyer, R. Van, A. Stegner, D. Edwards, J. Oh, J. Einerson, C. Korcarz, R. Koscik, M. Dowling, C. Gallagher, C. Carlsson, H. Rowley, B. Bendlin, S. Asthana, B. Hermann, M. Sager, J. Stein, S. Johnson, O. Okonkwo, and D. Cook. “Relationships Between Cardiorespiratory Fitness, Hippocampal Volume, and Episodic Memory in a Population at Risk for Alzheimer’s Disease.”. Brain and Behavior, Vol. 7, no. 3, 2017, p. e00625.

Cardiorespiratory fitness (CRF) has been shown to be related to brain health in older adults. In individuals at risk for developing Alzheimer’s disease (AD), CRF may be a modifiable risk factor that could attenuate anticipated declines in brain volume and episodic memory. The objective of this study was to determine the association between CRF and both hippocampal volume and episodic memory in a cohort of cognitively healthy older adults with familial and/or genetic risk for Alzheimer’s disease (AD).

DOI: 10.1002/brb3.625

PubMed: 28293467