Optimizing the intrinsic parallel diffusivity in NODDI: An extensive empirical evaluation.

Guerrero, J., N. Adluru, B. Bendlin, H. Goldsmith, S. Schaefer, R. Davidson, S. Kecskemeti, H. Zhang, and A. Alexander. “Optimizing the Intrinsic Parallel Diffusivity in NODDI: An Extensive Empirical Evaluation.”. PloS One, Vol. 14, no. 9, 2019, p. e0217118.

NODDI is widely used in parameterizing microstructural brain properties. The model includes three signal compartments: intracellular, extracellular, and free water. The neurite compartment intrinsic parallel diffusivity (d∥) is set to 1.7 μm2⋅ms-1, though the effects of this assumption have not been extensively explored. This work investigates the optimality of d∥ = 1.7 μm2⋅ms-1 under varying imaging protocol, age groups, sex, and tissue type in comparison to other biologically plausible values of d∥.

DOI: 10.1371/journal.pone.0217118

PubMed: 31553719