Clark, L., R. Koscik, C. Nicholas, O. Okonkwo, C. Engelman, L. Bratzke, K. Hogan, K. Mueller, B. Bendlin, C. Carlsson, S. Asthana, M. Sager, B. Hermann, and S. Johnson. “Mild Cognitive Impairment in Late Middle Age in the Wisconsin Registry for Alzheimer’s Prevention Study: Prevalence and Characteristics Using Robust and Standard Neuropsychological Normative Data.”. Archives of Clinical Neuropsychology : The Official Journal of the National Academy of Neuropsychologists, Vol. 31, no. 7, 2016, pp. 675-88.
Detecting cognitive decline in presymptomatic Alzheimer’s disease (AD) and early mild cognitive impairment (MCI) is challenging, but important for treatments targeting AD-related neurodegeneration. The current study aimed to investigate the utility and performance of internally developed robust norms and standard norms in identifying cognitive impairment in late middle-age (baseline age range = 36-68; M = 54).
PubMed: 27193363