Midlife measurements of white matter microstructure predict subsequent regional white matter atrophy in healthy adults.

Ly, M., E. Canu, G. Xu, J. Oh, D. McLaren, N. Dowling, A. Alexander, M. Sager, S. Johnson, and B. Bendlin. “Midlife Measurements of White Matter Microstructure Predict Subsequent Regional White Matter Atrophy in Healthy Adults.”. Human Brain Mapping, Vol. 35, no. 5, 2014, pp. 2044-54.

Although age-related brain changes are becoming better understood, midlife patterns of change are still in need of characterization, and longitudinal studies are lacking. The aim of this study was to determine if baseline fractional anisotropy (FA), obtained from diffusion tensor imaging (DTI) predicts volume change over a 4-year interval.

DOI: 10.1002/hbm.22311

PubMed: 23861348