Koscik, R., E. Jonaitis, L. Clark, K. Mueller, S. Allison, C. Gleason, R. Chappell, B. Hermann, and S. Johnson. “Longitudinal Standards for Mid-Life Cognitive Performance: Identifying Abnormal Within-Person Changes in the Wisconsin Registry for Alzheimer’s Prevention.”. Journal of the International Neuropsychological Society : JINS, Vol. 25, no. 1, 2019, pp. 1-14.
A major challenge in cognitive aging is differentiating preclinical disease-related cognitive decline from changes associated with normal aging. Neuropsychological test authors typically publish single time-point norms, referred to here as unconditional reference values. However, detecting significant change requires longitudinal, or conditional reference values, created by modeling cognition as a function of prior performance. Our objectives were to create, depict, and examine preliminary validity of unconditional and conditional reference values for ages 40-75 years on neuropsychological tests.
DOI: 10.1017/S1355617718000929
PubMed: 30482257