Insulin resistance predicts brain amyloid deposition in late middle-aged adults.

Willette, A., S. Johnson, A. Birdsill, M. Sager, B. Christian, L. Baker, S. Craft, J. Oh, E. Statz, B. Hermann, E. Jonaitis, R. Koscik, R. La, S. Asthana, and B. Bendlin. “Insulin Resistance Predicts Brain Amyloid Deposition in Late Middle-Aged Adults.”. Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association, Vol. 11, no. 5, 2015, pp. 504-510.e1.

Insulin resistance (IR) increases Alzheimer’s disease (AD) risk. IR is related to greater amyloid burden post-mortem and increased deposition within areas affected by early AD. No studies have examined if IR is associated with an in vivo index of amyloid in the human brain in late middle-aged participants at risk for AD.

DOI: 10.1016/j.jalz.2014.03.011

PubMed: 25043908