Hoscheidt, S., E. Starks, J. Oh, H. Zetterberg, K. Blennow, R. Krause, C. Gleason, L. Puglielli, C. Atwood, C. Carlsson, S. Asthana, S. Johnson, and B. Bendlin. “Insulin Resistance Is Associated With Increased Levels of Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease and Reduced Memory Function in At-Risk Healthy Middle-Aged Adults.”. Journal of Alzheimer’s Disease : JAD, Vol. 52, no. 4, 2016, pp. 1373-83.
Type 2 diabetes is associated with an increased risk for Alzheimer’s disease (AD). Regulation of normal insulin function may be important in reducing the prevalence of dementia due to AD, particularly in individuals who harbor genetic risk for or have a parental family history of AD. The relationship between insulin resistance (IR) and AD pathology remains poorly understood, particularly in midlife prior to the onset of clinical metabolic disease or cognitive decline.
DOI: 10.3233/JAD-160110
PubMed: 27079723