Willette, A., G. Xu, S. Johnson, A. Birdsill, E. Jonaitis, M. Sager, B. Hermann, R. La, S. Asthana, and B. Bendlin. “Insulin Resistance, Brain Atrophy, and Cognitive Performance in Late Middle-Aged Adults.”. Diabetes Care, Vol. 36, no. 2, 2013, pp. 443-9.
Insulin resistance dysregulates glucose uptake and other functions in brain areas affected by Alzheimer disease. Insulin resistance may play a role in Alzheimer disease etiopathogenesis. This longitudinal study examined whether insulin resistance among late middle-aged, cognitively healthy individuals was associated with 1) less gray matter in Alzheimer disease-sensitive brain regions and 2) worse cognitive performance.
DOI: 10.2337/dc12-0922
PubMed: 23069842