Family history of Alzheimer disease predicts hippocampal atrophy in healthy middle-aged adults.

Okonkwo, O., G. Xu, N. Dowling, B. Bendlin, A. Larue, B. Hermann, R. Koscik, E. Jonaitis, H. Rowley, C. Carlsson, S. Asthana, M. Sager, and S. Johnson. “Family History of Alzheimer Disease Predicts Hippocampal Atrophy in Healthy Middle-Aged Adults.”. Neurology, Vol. 78, no. 22, 2012, pp. 1769-76.

To evaluate the longitudinal influence of family history (FH) of Alzheimer disease (AD) and apolipoprotein E ε4 allele (APOE4) on brain atrophy and cognitive decline over 4 years among asymptomatic middle-aged individuals.

DOI: 10.1212/WNL.0b013e3182583047

PubMed: 22592366