Okonkwo, O., G. Xu, N. Dowling, B. Bendlin, A. Larue, B. Hermann, R. Koscik, E. Jonaitis, H. Rowley, C. Carlsson, S. Asthana, M. Sager, and S. Johnson. “Family History of Alzheimer Disease Predicts Hippocampal Atrophy in Healthy Middle-Aged Adults.”. Neurology, Vol. 78, no. 22, 2012, pp. 1769-76.
To evaluate the longitudinal influence of family history (FH) of Alzheimer disease (AD) and apolipoprotein E ε4 allele (APOE4) on brain atrophy and cognitive decline over 4 years among asymptomatic middle-aged individuals.
DOI: 10.1212/WNL.0b013e3182583047
PubMed: 22592366