Elevated Insulin and Insulin Resistance are Associated with Altered Myelin in Cognitively Unimpaired Middle-Aged Adults.

O’Grady, J., D. Dean, K. Yang, C. Canda, S. Hoscheidt, E. Starks, A. Merluzzi, S. Hurley, N. Davenport, O. Okonkwo, R. Anderson, S. Asthana, S. Johnson, A. Alexander, and B. Bendlin. “Elevated Insulin and Insulin Resistance Are Associated With Altered Myelin in Cognitively Unimpaired Middle-Aged Adults.”. Obesity (Silver Spring, Md.), Vol. 27, no. 9, 2019, pp. 1464-71.

Insulin regulates metabolism and influences neural health. Insulin resistance (IR) and type II diabetes have been identified as risk factors for Alzheimer disease (AD). Evidence has also suggested that myelinated white matter alterations may be involved in the pathophysiology of AD; however, it is unknown whether insulin or IR affect the underlying myelin microstructure. The relationships between insulin, IR, and myelin were examined, with the hypothesis that IR would be associated with reduced myelin.

DOI: 10.1002/oby.22558

PubMed: 31314172