Effects of simvastatin on white matter integrity in healthy middle-aged adults.

Vogt, N., J. Hunt, Y. Ma, H. Van, N. Adluru, R. Chappell, K. Lazar, L. Jacobson, B. Austin, S. Asthana, S. Johnson, B. Bendlin, and C. Carlsson. “Effects of Simvastatin on White Matter Integrity in Healthy Middle-Aged Adults.”. Annals of Clinical and Translational Neurology, Vol. 8, no. 8, 2021, pp. 1656-67.

The brain is the most cholesterol-rich organ and myelin contains 70% of total brain cholesterol. Statins are potent cholesterol-lowing medications used by millions of adults for prevention of vascular disease, yet the effect of statins on cholesterol-rich brain white matter (WM) is largely unknown.

DOI: 10.1002/acn3.51421

PubMed: 34275209