Vogt, N., J. Hunt, Y. Ma, H. Van, N. Adluru, R. Chappell, K. Lazar, L. Jacobson, B. Austin, S. Asthana, S. Johnson, B. Bendlin, and C. Carlsson. “Effects of Simvastatin on White Matter Integrity in Healthy Middle-Aged Adults.”. Annals of Clinical and Translational Neurology, Vol. 8, no. 8, 2021, pp. 1656-67.
The brain is the most cholesterol-rich organ and myelin contains 70% of total brain cholesterol. Statins are potent cholesterol-lowing medications used by millions of adults for prevention of vascular disease, yet the effect of statins on cholesterol-rich brain white matter (WM) is largely unknown.
DOI: 10.1002/acn3.51421
PubMed: 34275209