Carlsson, C., G. Xu, Z. Wen, J. Barnet, H. Blazel, R. Chappell, J. Stein, S. Asthana, M. Sager, D. Alsop, H. Rowley, S. Fain, and S. Johnson. “Effects of Atorvastatin on Cerebral Blood Flow in Middle-Aged Adults at Risk for Alzheimer’s Disease: A Pilot Study.”. Current Alzheimer Research, Vol. 9, no. 8, 2012, pp. 990-7.
Hypercholesterolemia in midlife increases risk for Alzheimer’s disease (AD) and contributes to cerebrovascular dysregulation – an early finding in preclinical AD pathology. Statins improve vascular reactivity, but it is unknown if they increase regional cerebral blood flow (CBF) in individuals at risk for AD.
DOI: 10.2174/156720512803251075
PubMed: 22175654