Effects of atorvastatin on cerebral blood flow in middle-aged adults at risk for Alzheimer’s disease: a pilot study.

Carlsson, C., G. Xu, Z. Wen, J. Barnet, H. Blazel, R. Chappell, J. Stein, S. Asthana, M. Sager, D. Alsop, H. Rowley, S. Fain, and S. Johnson. “Effects of Atorvastatin on Cerebral Blood Flow in Middle-Aged Adults at Risk for Alzheimer’s Disease: A Pilot Study.”. Current Alzheimer Research, Vol. 9, no. 8, 2012, pp. 990-7.

Hypercholesterolemia in midlife increases risk for Alzheimer’s disease (AD) and contributes to cerebrovascular dysregulation – an early finding in preclinical AD pathology. Statins improve vascular reactivity, but it is unknown if they increase regional cerebral blood flow (CBF) in individuals at risk for AD.

DOI: 10.2174/156720512803251075

PubMed: 22175654