Comparison of different MRI-based morphometric estimates for defining neurodegeneration across the Alzheimer’s disease continuum.

Allison, S., R. Koscik, R. Cary, E. Jonaitis, H. Rowley, N. Chin, H. Zetterberg, K. Blennow, C. Carlsson, S. Asthana, B. Bendlin, and S. Johnson. “Comparison of Different MRI-Based Morphometric Estimates for Defining Neurodegeneration across the Alzheimer’s Disease Continuum.”. NeuroImage. Clinical, Vol. 23, 2019, p. 101895.

Several neurodegeneration (N) metrics using structural MRI are used for the purpose of Alzheimer’s disease (AD)-related staging, including hippocampal volume, global atrophy, and an “AD signature” composite consisting of thickness or volumetric estimates derived from regions impacted early in AD. This study sought to determine if less user-intensive estimates of global atrophy and hippocampal volume were equivalent to a thickness-based AD signature from FreeSurfer for defining N across the AD continuum (i.e., individuals who are amyloid-positive (A+)).

DOI: 10.1016/j.nicl.2019.101895

PubMed: 31252287