Collective effects of age, sex, genotype, and cognitive status on fitness outcomes.

Morris, J., G. Zhang, R. Dougherty, J. Mahnken, C. John, S. Lose, D. Cook, J. Burns, E. Vidoni, and O. Okonkwo. “Collective Effects of Age, Sex, Genotype, and Cognitive Status on Fitness Outcomes.”. Alzheimer’s & Dementia (Amsterdam, Netherlands), Vol. 12, no. 1, 2020, p. e12058.

Individuals with Alzheimer’s disease (AD) broadly exhibit lower cardiorespiratory fitness (CRF) compared to cognitively healthy older adults. Other factors, such as increasing age and female sex, are also known to track with lower CRF levels. However, it is unclear how these factors together with AD diagnosis and genetic risk (apolipoprotein e4 ; APOE4) collectively affect CRF.

DOI: 10.1002/dad2.12058

PubMed: 32695870