Melah, K., S. Lu, S. Hoscheidt, A. Alexander, N. Adluru, D. Destiche, C. Carlsson, H. Zetterberg, K. Blennow, O. Okonkwo, C. Gleason, N. Dowling, L. Bratzke, H. Rowley, M. Sager, S. Asthana, S. Johnson, and B. Bendlin. “Cerebrospinal Fluid Markers of Alzheimer’s Disease Pathology and Microglial Activation Are Associated With Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer’s Disease.”. Journal of Alzheimer’s Disease : JAD, Vol. 50, no. 3, 2016, pp. 873-86.
The immune response in Alzheimer’s disease (AD) involves activation of microglia which may remove amyloid-β (Aβ). However, overproduction of inflammatory compounds may exacerbate neural damage in AD. AD pathology accumulates years before diagnosis, yet the extent to which neuroinflammation is involved in the earliest disease stages is unknown.
DOI: 10.3233/JAD-150897
PubMed: 26836182