Cardiorespiratory fitness attenuates age-associated aggregation of white matter hyperintensities in an at-risk cohort.

Vesperman, C., V. Pozorski, R. Dougherty, L. Law, E. Boots, J. Oh, C. Gallagher, C. Carlsson, H. Rowley, Y. Ma, B. Bendlin, S. Asthana, M. Sager, B. Hermann, S. Johnson, D. Cook, and O. Okonkwo. “Cardiorespiratory Fitness Attenuates Age-Associated Aggregation of White Matter Hyperintensities in an at-Risk Cohort.”. Alzheimer’s Research & Therapy, Vol. 10, no. 1, 2018, p. 97.

Age is the cardinal risk factor for Alzheimer’s disease (AD), and white matter hyperintensities (WMH), which are more prevalent with increasing age, may contribute to AD. Higher cardiorespiratory fitness (CRF) has been shown to be associated with cognitive health and decreased burden of AD-related brain alterations in older adults. Accordingly, the aim of this study was to determine whether CRF attenuates age-related accumulation of WMH in middle-aged adults at risk for AD.

DOI: 10.1186/s13195-018-0429-0

PubMed: 30249285