Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD.

Schultz, S., E. Boots, B. Darst, H. Zetterberg, K. Blennow, D. Edwards, R. Koscik, C. Carlsson, C. Gallagher, B. Bendlin, S. Asthana, M. Sager, K. Hogan, B. Hermann, D. Cook, S. Johnson, C. Engelman, and O. Okonkwo. “Cardiorespiratory Fitness Alters the Influence of a Polygenic Risk Score on Biomarkers of AD.”. Neurology, Vol. 88, no. 17, 2017, pp. 1650-8.

To examine whether a polygenic risk score (PRS) derived from APOE4, CLU, and ABCA7 is associated with CSF biomarkers of Alzheimer disease (AD) pathology and whether higher cardiorespiratory fitness (CRF) modifies the association between the PRS and CSF biomarkers.

DOI: 10.1212/WNL.0000000000003862

PubMed: 28341646