Willette, A., B. Bendlin, E. Starks, A. Birdsill, S. Johnson, B. Christian, O. Okonkwo, R. La, B. Hermann, R. Koscik, E. Jonaitis, M. Sager, and S. Asthana. “Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease.”. JAMA Neurology, Vol. 72, no. 9, 2015, pp. 1013-20.
Converging evidence suggests that Alzheimer disease (AD) involves insulin signaling impairment. Patients with AD and individuals at risk for AD show reduced glucose metabolism, as indexed by fludeoxyglucose F 18-labeled positron emission tomography (FDG-PET).
DOI: 10.1001/jamaneurol.2015.0613
PubMed: 26214150