Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease.

Raghavan, N., L. Dumitrescu, E. Mormino, E. Mahoney, A. Lee, Y. Gao, M. Bilgel, D. Goldstein, T. Harrison, C. Engelman, A. Saykin, C. Whelan, J. Liu, W. Jagust, M. Albert, S. Johnson, H. Yang, K. Johnson, P. Aisen, S. Resnick, R. Sperling, J. De, J. Schneider, D. Bennett, M. Schrag, B. Vardarajan, T. Hohman, R. Mayeux, and D. Alzheimer’s. “Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease.”. JAMA Neurology, 2020.

Genetic studies of Alzheimer disease have focused on the clinical or pathologic diagnosis as the primary outcome, but little is known about the genetic basis of the preclinical phase of the disease.

DOI: 10.1001/jamaneurol.2020.1760

PubMed: 32568366