Neu, S., J. Pa, W. Kukull, D. Beekly, A. Kuzma, P. Gangadharan, L. Wang, K. Romero, S. Arneric, A. Redolfi, D. Orlandi, G. Frisoni, R. Au, S. Devine, S. Auerbach, A. Espinosa, M. Boada, A. Ruiz, S. Johnson, R. Koscik, J. Wang, W. Hsu, Y. Chen, and A. Toga. “Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-Analysis.”. JAMA Neurology, Vol. 74, no. 10, 2017, pp. 1178-89.
It is unclear whether female carriers of the apolipoprotein E (APOE) ε4 allele are at greater risk of developing Alzheimer disease (AD) than men, and the sex-dependent association of mild cognitive impairment (MCI) and APOE has not been established.
DOI: 10.1001/jamaneurol.2017.2188
PubMed: 28846757