Koscik, R., T. Betthauser, E. Jonaitis, S. Allison, L. Clark, B. Hermann, K. Cody, J. Engle, T. Barnhart, C. Stone, N. Chin, C. Carlsson, S. Asthana, B. Christian, and S. Johnson. “Amyloid Duration Is Associated With Preclinical Cognitive Decline and Tau PET.”. Alzheimer’s & Dementia (Amsterdam, Netherlands), Vol. 12, no. 1, 2020, p. e12007.
This study applies a novel algorithm to longitudinal amyloid positron emission tomography (PET) imaging to identify age-heterogeneous amyloid trajectory groups, estimate the age and duration (chronicity) of amyloid positivity, and investigate chronicity in relation to cognitive decline and tau burden.
DOI: 10.1002/dad2.12007
PubMed: 32211502