Jonaitis, E., R. Koscik, R. La, S. Johnson, B. Hermann, and M. Sager. “Aging, Practice Effects, and Genetic Risk in the Wisconsin Registry for Alzheimer’s Prevention.”. The Clinical Neuropsychologist, Vol. 29, no. 4, 2015, pp. 426-41.
In the last five years, a consensus has developed that Alzheimer’s disease (AD) may begin years before overt cognitive impairment. Accordingly, the focus has shifted to identifying preclinical disease in order to match treatments to those most likely to benefit. Subtle cognitive changes, including reduced benefit from practice, may be one such preclinical sign. In this study, we explore cognitive aging trajectories within a large cohort of clinically intact late middle-aged adults.
DOI: 10.1080/13854046.2015.1047407
PubMed: 26012360