Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β-amyloid accumulation.

Racine, A., R. Koscik, C. Nicholas, L. Clark, O. Okonkwo, J. Oh, A. Hillmer, D. Murali, T. Barnhart, T. Betthauser, C. Gallagher, H. Rowley, N. Dowling, S. Asthana, B. Bendlin, K. Blennow, H. Zetterberg, C. Carlsson, B. Christian, and S. Johnson. “Cerebrospinal Fluid Ratios With Aβ42 Predict Preclinical Brain β-Amyloid Accumulation.”. Alzheimer’s & Dementia (Amsterdam, Netherlands), Vol. 2, 2016, pp. 27-38.

Biomarkers are urgently needed for the critical yet understudied preclinical stage of Alzheimer’s disease (AD).

DOI: 10.1016/j.dadm.2015.11.006

PubMed: 26955655